Are synthetic supplements as effective as natural ones?

Are synthetic supplements as effective as natural ones?
Although synthetic nutrients are structurally identical to wholefood nutrients, they are created in a very different way and they exist in isolation without the surrounding plant/food co-factors and enzymes that are also ingested when you eat food, which aids digestion and absorption.
The are conflicting results from scientific studies as to how well synthetic nutrients are absorbed and used by the body. Some research shows that some are more easily absorbed than others 1 and that an isolated nutrient is unlikely to deliver the health benefits that eating food would 2 .
Eloments contains co-factors and co-nutrients which are extracted along with the primary vitamin or mineral, making it more recognisable by the gut and more likely to be absorbed.
Healthline [Red] states that whilst wholefood supplements show clear health benefits, evidence for synthetic supplementation is less certain 3 .
Following are a small sample of a few of the mixed findings from recognised, reputable studies;
● Natural vitamin E has roughly twice the availability of synthetic vitamin E 4
● Long-term use of multivitamins may substantially reduce risk for colon cancer. This effect may be related to the folic acid contained in multivitamins 5
● Use of low dose multivitamin supplements may aid in the primary prevention of myocardial infarction (heart attack) 6
● Multivitamin use has little or no influence on the risk of common cancers, CVD, or total mortality in postmenopausal women 7

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